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More specifically, this may be observed with respect to certain genes, including Egr, Nos, Srf, Vegr, Akt1, Plcɣ , and Kras genes (Vukojevic et al., 2018), all of which are responsible for the synthesis of factors necessary for a diverse set of processes
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The research specifically shows that stressing out rats with mild stressors for 40 days causes increases in oxidative stress, including increases in SOD (superoxide dismutase).[ref] (We will return to SOD in a minute.) How does the dysregulation of the HPA axis and altered cortisol levels cause mitochondrial dysfunction